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    Anti-CHK2 antibody
    • 品牌:OminimAbs
    • 产地:上海
    • 型号:毫升
    • 货号:电询
    • 发布日期: 2024-08-26
    • 更新日期: 2024-10-09
    产品详请
    产地 上海
    品牌 OminimAbs
    保存条件
    货号 电询
    用途 实验研究
    应用范围 科研实验
    抗原来源 电询
    保质期 2年
    抗体名 电询
    是否单克隆
    克隆性
    靶点 电询
    适应物种 电询
    形态 电询
    宿主 电询
    标记物 电询
    包装规格 毫升
    亚型 电询
    标识物 电询
    浓度 电询%
    免疫原 电询
    是否进口

    Product Profile

    Product Name

    Anti-CHK2 antibody

    Antibody Type

    Primary Antibodies

    Immunogen

    Recombinent Proteins

    Key Feature

    Clonality

    Monoclonal

    Isotype

    IgG

    Host Species

    Mouse

    Tested Application

    ELISAICC/IFIHCWB

    WB:1:200-1:2000
    IHC:1:200-1:1000
    ICC/IF:1:100-1:500

    Species Reactivity

    HumanRabbit

    Concentration

    1 mg/ml

    Purification

    Protein A

    Target Information

    Gene Symbol

    CHEK2

    Gene Synonyms

    CDS1
    LFS2
    RAD53
    hCds1
    HuCds1
    PP1425

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    Gene Full Name

    checkpoint kinase 2

    Gene Summary

    In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

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    Molecular Weight(MW)

    61 kDa

    Source

    Mouse

    Cellular Localizatio

    Nucleus

    Application

    ·        

    WB

    Western blot analysis using CHK2 antibody against Hep G2 (1) cell lysate.

    ·        

    IHC

    Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using CHK2 antibody with DAB staining.

    ·        

    ICC/IF

    Immunofluorescence analysis of HepG2 cells using CHK2 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

    Application Notes

    WB:1:200-1:2000
    IHC:1:200-1:1000
    ICC/IF:1:100-1:500

    Additional Information

    Form

    Liquid

    Storage Instruction

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

    Storage Buffer

    Purified antibody in PBS with 0.05% sodium azide.


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