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Product Profile

Product Name	Anti-E-Cadherin antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAIHCWB
	WB:1:200-1:2000 IHC:1:200-1:1000
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml
Purification	Protein A

Target Information

Gene Symbol	CDH1
Gene Synonyms	UVO CDHE ECAD LCAM Arc-1 BCDS1 CD324 Hide
Gene Full Name	cadherin 1
Gene Summary	This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015] Hide
Molecular Weight(MW)	97 kDa（Observed:120 kDa）
Cellular Localizatio	Cell junction, Cell membrane, Endosome, Golgi apparatus.

Application

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WB

Western blot analysis using E-Cadherin antibody against A549(1), A431(2), HEK293(3) cell lysate.

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IHC

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using E-Cadherin antibody with DAB staining.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:1000

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.