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Product Profile

Product Name	Anti-MCM2 antibody
Antibody Type	Primary Antibodies
Product description	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAIHCWB
	WB:1:200-1:2000 IHC:1:200-1:2000
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Protein A

Target Information

Gene Symbol	MCM2
Gene Synonyms	BM28 CCNL1 CDCL1 cdc19 DFNA70 D3S3194 MITOTIN Hide
Gene Full Name	minichromosome maintenance complex component 2
Gene Summary	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012] Hide
Molecular Weight(MW)	102kD(Observed:90 kD）
Cellular Localizatio	Chromosome, Nucleus

Application

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WB

Western blot analysis using MCM2 antibody against Hela(1) cell lysate.

        

IHC

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using MCM2 antibody with DAB staining.

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IHC

Immunohistochemical analysis of paraffin-embedded colon cancer tissues tissues using MCM2 antibody with DAB staining.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:2000

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.