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    产品展厅
    Anti-TLR4 antibody Catalog Number:OM641714
    • 品牌:OminimAbs
    • 产地:上海
    • 型号:毫升
    • 货号:OM641714
    • 发布日期: 2024-09-14
    • 更新日期: 2024-10-09
    产品详请
    产地 上海
    品牌 OminimAbs
    保存条件
    货号 OM641714
    用途 实验研究
    应用范围 科研实验
    抗原来源 电询
    保质期 2年
    抗体名 电询
    是否单克隆
    克隆性
    靶点 电询
    适应物种 电询
    形态 电询
    宿主 电询
    标记物 电询
    包装规格 毫升
    亚型 电询
    标识物 电询
    浓度 电询%
    免疫原 电询
    是否进口

    Product Profile

    Product Name

    Anti-TLR4 antibody

    Antibody Type

    Primary Antibodies

    Immunogen

    Polypeptide

    Key Feature

    Clonality

    Polyclonal

    Isotype

    IgG

    Host Species

    Rabbit

    Tested Application

    ELISAIHC

    IHC:1:200-1:1000

    Species Reactivity

    HumanMouseRat

    Concentration

    1 mg/ml

    Purification

    Protein A

    Target Information

    Gene Symbol

    TLR4

    Gene Synonyms

    TOLL
    CD284
    TLR-4
    ARMD10

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    Gene Full Name

    toll like receptor 4

    Gene Summary

    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

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    Source

    Rabbit

    Cellular Localizatio

    Plasma membrane; Endosome

    Application

    ·        

    IHC

    Immunohistochemical analysis of paraffin-embedded rectal cancer tissues using TLR4 antibody with DAB staining

    ·        

    IHC

    Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using TLR4 antibody with DAB staining.

    Application Notes

    IHC:1:200-1:1000

    Additional Information

    Form

    Liquid

    Storage Instruction

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

    Storage Buffer

    Purified antibody in PBS with 0.05% sodium azide.


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